Emerging Concepts in Basic Science

Impact of Medical Comorbidities on Accumulation of ADRD Neuropathology and Biomarker Readouts

Chaired by Thomas Beach, Banner Sun Health Research Institute, United States and Michelle Mielke, Wake Forest University, United States.

• Impact of Comorbidities on Biomarkers of Alzheimer's Disease and Related Dementias
  Presented by Michelle Mielke, Wake Forest University, United States.
• Extent and Clinical Effects of AD Comorbidities in Longitudinal Clinicopathological Studies
  Presented by Thomas Beach, Banner Sun Health Research Institute, United States.
• Impact of Blood-Brain Barrier Integrity on Plasma AD Biomarkers
  Presented by Bruna Bellaver, University of Pittsburgh, United States.
• Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia
  Presented by Pamela McLean, Mayo Clinic, United States.

Crosstalk Between Oligodendrocytes, Astrocytes and Microglia

Chaired by Shin Kang, Temple University, United States and Sudesha Das, Massachusetts General Hospital, United States.

• Understanding Glia Interaction with Synapses
  Presented by Beth Stevens, Harvard Medical School, United States.
• Crosstalk Between Microglia and Astrocytes
  Presented by Eduardo R. Zimmer, Universidade Federal do Rio Grande do Sul, Brazil.
• Oligodendrocytes
  Presented by Shin Kang, Temple University, United States.
• The Next Generation of Spatial Transcriptomics and AI to Understand Complex Interactions Between Glial Cells
  Presented by Sudeshna Das, Massachusetts General Hospital, United States.

The Role of Tau in Cerebrovascular Disease

Chaired by Luc Buée, University of Lille, France and Veronica Galvan, The University of Oklahoma, United States.

• Tau in Vascular Remodeling and Blood-Brain Barrier Dysfunction in AD
  Presented by Rachel Bennet, Harvard Medical School, United States.
• Tanycyte-Mediated Brain-to-Blood Efflux of Tau is Disrupted in AD
  Presented by Florent Sauve, Uppsala University, Sweden.
• Tau Transmission: A key Driver of Senescence in Non-Neuronal Brain Cells
  Presented by Veronica Galvan, The University of Oklahoma, United States.
• Cis p-tau Underlies Vascular Contribution to Cognitive Impairment and Dementia
  Presenter to be determined.